Next generation pharmacokinetic-pharmacodynamic modeling: dosage regimen for both curative and metaphylactic antimicrobial treatment taking antimicrobial resistance development into account

01 January 2017 → 31 October 2021
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
antimicrobials curative treatment broiler chicken
Project description

Current dosage regimens of antimicrobials have been determined for curative treatment without taking antimicrobial resistance into account. In this research proposal, optimal dosage regimen will be established for both curative and metaphylactic enrofloxacin treatment against avian pathogenic Escherichia coli in broilers. The effect of these dosage regimen on resistance development in both the target pathogen and the commensal gut microbiota will be evaluated.