Identification of chemical compounds that specifically interact with Arctical, a novel interactor of Arabidopsis Auroral, using chemical genetics

01 January 2008 → 31 December 2010
Research Foundation - Flanders (FWO)
Research disciplines
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
confocal microscopy green fluorescing protein cell biology plant cytokinesis
Project description

Aurora kinases play key roles during eukaryotic cytokinesis. Recently we identified an interactor of Arabidopsis Aurora1 (Arctica1). This protein has a polar localization in Tobacco suspension cells. The aim of this project is to identify chemical compounds that specifically interfere with this localization. This will be achieved by the development of a screening platform using confocal and epifluorescence techniques.