Research Explorer

Project

Signalling mechanisms of the NLRP1b inflammasome in innate immunity

Code
3E025315
Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
pyroptosis and apoptosis Nlrp1b LeTx
 
Project description
 

The NLRP1 inflammasome is triggered by anthrax lethal toxin (LeTx) and mutations in NLRP1 are associated with autoimmune diseases including vitiligo, lupus and diabetes type 1. To enable better therapeutic intervention, it is imperative to characterize the NLRP1b inflammasome pathway fully. Our preliminary data show that LeTx-treatment shifts towards apoptosis when caspase-1 is absent, but the mechanisms involved are unknown.