Genome-wide transcription factor-DNA recruitment and surrounding cofactorprofiling at combined GRα- and PPARα-based transcriptional cross-talk mechanisms.

01 January 2009 → 31 December 2014
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
glucocorticoids gene expression PPAR agonists hormone regulation
Project description

Recently our research group demonstrated in collaboration with the group of Prof. Bart Staels (Pasteur Institute Lille) that upon combining glucocorticoids with PPAR agonists, an additive anti-inflammatory effect is established, surprisingly in the absence of diabetogenic side effects (Bougarne et al., Proc. Natl. Acad. Sci., 2009). The current research proposal will focus on determining the underlying molecular mechanisms allowing to explain the cross-talk between PPAR and GR.