Code
01SC9518
Duration
01 July 2018 → 30 November 2019
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics not elsewhere classified
-
Medical and health sciences
- Endocrinology and metabolic diseases not elsewhere classified
- Gynaecology and obstetrics not elsewhere classified
- Molecular and cell biology not elsewhere classified
- Morphological sciences not elsewhere classified
- Endocrinology and metabolic diseases not elsewhere classified
- Gynaecology and obstetrics not elsewhere classified
- Molecular and cell biology not elsewhere classified
- Morphological sciences not elsewhere classified
- Nursing not elsewhere classified
- Endocrinology and metabolic diseases not elsewhere classified
- Gynaecology and obstetrics not elsewhere classified
- Molecular and cell biology not elsewhere classified
- Morphological sciences not elsewhere classified
Keywords
Nuclear transfer
mitochondrial disease
infertility
oocyte
embryo
pluripotent stem cell
Project description
Since mitochondrial DNA (mtDNA) diseases can not be cured, their prevention is an absolute priority. Recently, germline nuclear transfer (NT) has been proposed as novel technique for preventing mutant mtDNA transmission and for some infertility cases. For safety and efficacy issues, further optimization and validation of these NT techniques by using animal models is necessary prior to their clinical translation.