Project

Nuclear transfer technology for the prevention of mitochondrial diseases and infertility

Code
01SC9518
Duration
01 July 2018 → 30 November 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Endocrinology and metabolic diseases
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Nursing
    • Endocrinology and metabolic diseases
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
Keywords
Nuclear transfer mitochondrial disease infertility oocyte embryo pluripotent stem cell
 
Project description

Since mitochondrial DNA (mtDNA) diseases can not be cured, their prevention is an absolute priority. Recently, germline nuclear transfer (NT) has been proposed as novel technique for preventing mutant mtDNA transmission and for some infertility cases. For safety and efficacy issues, further optimization and validation of these NT techniques by using animal models is necessary prior to their clinical translation.