Identification and functional evaluation of Arabidopsis metacaspase substrates

01 January 2009 → 31 December 2014
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • General biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
arabidopsis metacaspases cell death
Project description

The project aimes to unravel the function of metacaspases in plants (and fungi and protozoans). To achieve this major goal, the project will pursue the following sub-objectives: 1. Detailed phenotypic and biochemical analysis of transgenic lines with perturbed AtMC9/4 (a type II metacaspase) levels. 2. Discovery of metacaspase inhibitors 3. Proteome-wide identification of protein substrates for AtMC9/4 4. Functional analysis of AtMC9/4 protein substrates.