Project

Identification and functional evaluation of Arabidopsis metacaspase substrates

Code

3G003809

Duration

01 January 2009 → 31 December 2014

Funding

Research Foundation - Flanders (FWO)

Promotor

Frank Van Breusegem

Research disciplines

Natural sciences
- Biochemistry and metabolism
- General biology
- Plant biology
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Keywords

arabidopsis metacaspases cell death

Project description

The project aimes to unravel the function of metacaspases in plants (and fungi and protozoans). To achieve this major goal, the project will pursue the following sub-objectives: 1. Detailed phenotypic and biochemical analysis of transgenic lines with perturbed AtMC9/4 (a type II metacaspase) levels. 2. Discovery of metacaspase inhibitors 3. Proteome-wide identification of protein substrates for AtMC9/4 4. Functional analysis of AtMC9/4 protein substrates.