Research Explorer

Project

The role of prolyl hydroxylases in endothelial dysfunction in the pathogenesis of Non-Alcoholic Steatohepatitis
Code
3F014615
Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
Non-alcoholic steatohepatitis endothelial dysfunction
 
Project description
 

Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation and fat accumulation. Pathological neo-angiogenesis is a crucial factor in experimental NASH. With this project we aim to clarify the role of prolyl hydroxylases (PHD), the cellular oxygen sensors, in NASH. The expression of PHDs and the effects of PHD inhibition will be evaluated in human samples and murine models respectively.