Project

The development of HPLC-ICP-MS methods for metabolite profiling of medical drugs

Code
01SC0418
Duration
01 July 2018 → 30 September 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Analytical chemistry not elsewhere classified
  • Medical and health sciences
    • Pharmaceutical analysis and quality assurance not elsewhere classified
Keywords
HPLC-ICP-MS metabolite profiling ADME derivatisation
 
Project description

The capabilities of liquid chromatography, coupled to ICP-mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of drugs containing an ICP-MS detectable element have already been demonstrated at UGent. In this project, derivatization protocols will be developed for drugs that do not contain such an element, in order to extend the application range of HPLC-ICP-MS for quantitative metabolite profiling of drug molecules, as alternative to HPLC with radiodetection.