Code
01SC0418
Duration
01 July 2018 → 30 September 2019
Funding
Regional and community funding: Special Research Fund
Promotor
Fellow
Research disciplines
-
Natural sciences
- Analytical chemistry not elsewhere classified
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Medical and health sciences
- Pharmaceutical analysis and quality assurance not elsewhere classified
Keywords
HPLC-ICP-MS
metabolite profiling
ADME
derivatisation
Project description
The capabilities of liquid chromatography, coupled to ICP-mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of drugs containing an ICP-MS detectable element have already been demonstrated at UGent. In this project, derivatization protocols will be developed for drugs that do not contain such an element, in order to extend the application range of HPLC-ICP-MS for quantitative metabolite profiling of drug molecules, as alternative to HPLC with radiodetection.