Code
3E014714
Duration
01 October 2014 → 01 November 2019
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Cardiac and vascular medicine
- Laboratory medicine
- Medical systems biology
- Cardiac and vascular medicine
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Cardiac and vascular medicine
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
Keywords
fibrillin-1
aortic aneurysms
TGF-beta
heritable connective tissue disorders
exome sequencing
cardiovascular system
genetics
marfan syndrome
cardiomyopathy
Project description
This project aims to gain more insights into the molecular and cellular mechanisms contributing to Marfan syndrome (MFS)-related aortic- and cardiac disease by studying different pathways, cellular behaviour and cell-matrix interactions in MFS mouse models.
In addition, we aim to identify new genes in patients and families with genetically unexplained thoracic aortic aneurysms and dissections using a whole exome sequencing approach.