The goal of this project is to release pig MRSA, or to obtain at least a substantial reduction of the colonization, and thus reduce or prevent the risk of infection of humans. In order to achieve this, phage endolysins overproduced in E. coli or Pichia pastoris. They will then be purified for use in the in vivo treatment of experimentally infected animals. The developing pesticide is based on enzymes produced by bacteriophages and will be used to clear MRSA from animals, or to obtain a substantial reduction.