Leaks and plugs: unveiling teh role of compartmentalization in laminopathic models with intelligent imaging and location proteomics

01 January 2011 → 01 October 2013
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Medicinal and biomolecular chemistry
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
    • Biophysics
    • Molecular and cell biology
  • Engineering and technology
    • Multimedia processing
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
    • Signal processing
bio-imaging nuclear organisation lamina
Project description

The objective is to elucidate the influnce of lamin mutations on cell function in the context of ageing diseases.Intracellular compartmentalization and spatiotemporal dynamics of singaling molecules will be studied using advanced microscopy and molecular-biochemical analyses. With this work, we intend to link structural defects with cell function and thereby create a fundamental understanding of the development of laminopathies.