In vitro liver model selection/development/characterization: Evaluation of the human liver-uPA/SCID mouse model as a new source of human hepatocytes suitable for establishing human liver 3D co-cultures



Pharmacokinetics/ Humanized mice as in vivo model to predict human metabolism/Pharmacokinetics



Drug Induced Liver Injury / Prediction of human-specific liver toxicity based on in vitro 3D liver models and humanized animals