Project

Development of human liver 3D co-cultures as translational research and development platform

Duration
01 November 2012 → 01 July 2016
Funding
Private funding via IWT/VLAIO
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Laboratory medicine
    • Laboratory medicine
Keywords
liver 3D co-cultures
 
Project description

In vitro liver model selection/development/characterization: Evaluation of the human liver-uPA/SCID mouse model as a new source of human hepatocytes suitable for establishing human liver 3D co-cultures



Pharmacokinetics/ Humanized mice as in vivo model to predict human metabolism/Pharmacokinetics



Drug Induced Liver Injury / Prediction of human-specific liver toxicity based on in vitro 3D liver models and humanized animals