Research Explorer

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Project

Worming a way to extend life: protein turnover or protein stabilization?

Outputs and Outcomes

Code

01J01315

Duration

01 September 2015 → 30 April 2021

Funding

Regional and community funding: Special Research Fund

Promotor

Bart Braeckman

Research disciplines

Natural sciences
- Animal biology
- Biochemistry and metabolism
- General biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
Agricultural and food sciences
- Veterinary medicine

Keywords

aging C. elegans protein turnover trehalose autophagy

Project description

We will study the paradoxal finding that, in order to extend life of the nematode Caenorhabditis elegans, autophagy is required, while protein turnover and lysosomal function are decreased. We will also study the importance of protein stabilization via trehalose in this process.

English

Dutch

English

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