Project

Worming a way to extend life: protein turnover or protein stabilization?

Duration
01 September 2015 → 30 April 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • General biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
aging C. elegans protein turnover trehalose autophagy
 
Project description

We will study the paradoxal finding that, in order to extend life of the nematode Caenorhabditis elegans, autophagy is required, while protein turnover and lysosomal function are decreased. We will also study the importance of protein stabilization via trehalose in this process.