Project

The role of PHF6 in normal T-cell development and T-cell acute lymphoblastic leukemia

Duration
09 December 2010 → 08 December 2011
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
T-ALL T-cell leukemia tumor suppressor PHF6
 
Project description

T-ALL results from the malignant transformation of thymocytes and mainly affects children. Recently, PHF6 was identified as a novel tumor suppressor gene in T-ALL at the Center of Medical Genetics Ghent. The aim of this project is to investigate the role of PHF6 in the development of normal T-cells and T-ALL and to unravel transcriptional networks regulated by PHF6.