Research Explorer

Project

Innate imprinting of resident alveolar macrophages by allergic airway inflammation: mechanism and consequences for asthma exacerbation
Code
3F013813
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
Keywords
exacerbation asthma mouse model Inflammation alveolar macrophages
 
Project description
 

In a mouse model of asthma, resident alveolar macrophages showed an increased inflammatory reactivity upon post-infection of the asthmatic lung. This project aims to elucidate the mechanism underlying the altered macrophage innate functionality and hereby to enable interference with asthma exacerbation.