Project

Early events in the interaction of antigens/microorganisms with the intestinal epithelial cells and intestinal dendritic cells : development of new innovative oral delivery system.

Duration
01 January 2010 → 17 May 2016
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Immunology
    • Immunology
    • Microbiology
    • Public health care
    • Public health sciences
    • Public health services
    • Immunology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
dendritic cells PEM microparticles
 
Project description

Vaccination is regarded as the most efficient and cost-effective way to prevent infectious diseases.

Vaccine design nowadays focuses on the implementation of safer recombinant subunit vaccines. However, these recombinant subunit antigens are often poor immunogens and several strategies are currently under investigation to enhance their immunogenicity. The encapsulation of the antigens in biodegradable microparticulate delivery systems seems a promising strategy to boost their immunogenicity. Here, we evaluate the capacity of polyelectrolyte microparticles (PEMs), fabricated by single step spray-drying, to deliver antigens to porcine dendritic cells and how these particles affect the functional maturation of dendritic cells (DCs).