Project

MYCN deregulated transcription in neuroblastome: study of direct mRNA and miRNA regulated target genes

Duration
01 January 2007 → 31 December 2010
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
neuroblastoma genetics cancer
 
Project description

Neuroblastoma is the most frequent extracranial solid tumour in children. Despite the existence of multimodal treatments, the prognosis of most patients remains unfavourable. A subgroup of aggressive neuroblastoma tumours is characterised by amplification of the MYCN transcription factor. The identification of new MYCN target genes could result in improved treatment stategies.