Research Explorer

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Project

Role of ZEB2 in T-cell acute lymphoblastic leukemia (T-ALL) initiation and Progression

Outputs and Outcomes

Code

365P5613

Duration

01 January 2013 → 31 December 2015

Funding

Funding by bilateral agreement (private and foundations)

Promotor

Geert Berx

Research disciplines

Natural sciences
- Systems biology
Medical and health sciences
- Hematology
- Laboratory medicine
- Morphological sciences
- Oncology
- Hematology
- Laboratory medicine
- Morphological sciences
- Oncology
- Hematology
- Laboratory medicine
- Morphological sciences
- Oncology

Keywords

leukemia mouse model stem cells

Project description

High ZEB2 levels were seen in ETP-ALL and preliminary data from our novel conditional overexpression mouse model suggests a key role for this transcription factor in T-ALL. Here we will investigate whether Zeb2 is altering the formation/function of leukemic cancer stem cells in this aggressive subtype of T-ALL.

English

Dutch

English

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