Code
365P5613
Duration
01 January 2013 → 31 December 2015
Funding
Funding by bilateral agreement (private and foundations)
Promotor
Research disciplines
-
Natural sciences
- Systems biology
-
Medical and health sciences
- Hematology
- Laboratory medicine
- Morphological sciences
- Oncology
- Hematology
- Laboratory medicine
- Morphological sciences
- Oncology
- Hematology
- Laboratory medicine
- Morphological sciences
- Oncology
Keywords
leukemia
mouse model
stem cells
Project description
High ZEB2 levels were seen in ETP-ALL and preliminary data from our novel conditional overexpression mouse model suggests a key role for this transcription factor in T-ALL. Here we will investigate whether Zeb2 is altering the formation/function of leukemic cancer stem cells in this aggressive subtype of T-ALL.