The VIB-GCP PID-consortium will address the urgent need for mechanistic understanding and molecular diagnostic tools to better stratify PID patients and guide therapeutic decisions in the clinic. Additionally, research of novel targeted therapeutic concepts based on deep insight in the core immunological and molecular mechanisms driving specific PID will expand therapeutic options available to physicians and their patients. Not only will this have important and immediate impact on the life of affected patients, it will also have tremendous scientific impact in reverse translational research.