Project

Evaluation of halogenated imines and electrophilic allyl halides in the asymmetric synthesis of new conformationally constrained beta-amino acids

Duration
01 October 2007 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Other chemical sciences
  • Agricultural and food sciences
    • Agricultural plant production
Keywords
beta-amino acids azaheterocyclic compounds asymmetric synthesis cycloalkanes
 
Project description

In view of the success of halogenated imines and electrophilic allyl halides as building blocks in synthetic organic chemistry, these compounds are promising substrates for the chiral synthesis of heterocyclic and carbocyclic beta-amino acids. In this project the asymmetric synthesis of new conformationally constrained beta-amino acid derivatives and analogues is developed based on Michael- and Mannich-additions and reactions of 1-azaallylic anions.