Research Explorer

Project

Study of biological mechanisms involved in heritable connective tissue disorders, using the Ehlers-Danlos Syndrome as a paradigm
Code
3G023811
Duration
01 January 2011 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Dermatology
    • Molecular and cell biology
    • Orthopaedics
    • Dermatology
    • Orthopaedics
    • Dermatology
    • Molecular and cell biology
    • Orthopaedics
Keywords
ehlers-Danlos syndrome mouse model ZNF469 allagen III
 
Project description

This project aims at the identification of new genes for various Ehlers-Danlos syndrome (EDS) subtypes, a heritable genodermatosis, as well as the analysis of the function of ZNF469, found to contain mutations in the Brittle Cornea Syndrome, a condition overlapping with EDS, and finally the creation of a mouse model for the vascular EDS subtype.