Research Explorer

Project

Star-shaped polymer based antibody-drug conjugates
Acronym
3pl004316
Code
3PL04316W
Duration
01 June 2017 → 31 May 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Macromolecular and materials chemistry
  • Engineering and technology
    • Process engineering
    • Biomaterials engineering
    • Polymeric materials
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
antibody polymer targeting
 
Project description
 

Polymers loaded with anti-cancer drugs represent excellent tools for cancer treatment. During this project star-shaped drug delivery systems will be developed consisting of an antibody "core", which will be site-specifially modified with biocompatible polymer arms covalently preloaded with anticancer drugs. This system will be rapidly accumulated in the tumor tissue, where the drug will be released in a controlled way.