Project

Protection against influenza A virus infection and modulation of antigen presentation by matrix protein 2-specific antibodies.

Duration
01 January 2015 → 31 December 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Infectious diseases
    • Virology
    • Pathophysiology
    • Vaccinology
    • Vaccines
Keywords
M2e immunity antigen presentation influenza
 
Project description

Matrix protein 2 ectodomain (M2e) specific antibodies protect against disease caused by influenza A viruses. M2e-based immune protection is infection permissive, meaning that viral replication is blunted but not prevented. In this project, we will study if and how M2e-based immune protection modulates the adaptive immune response following challenge.