Project

Red and processed meat in the diet: toxicological and metabolomic profiling under simulated gastrointestinal conditions

Duration
01 January 2015 → 31 December 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Food chemistry
  • Medical and health sciences
    • Medical metabolomics
    • Public health nutrition
    • Medical lipidomics
  • Agricultural and food sciences
    • Veterinary public health and food safety
Keywords
meat metabolomics cell cultures digestion nutrition
 
Project description

The role of digestion as a factor in the colorectal cancer promoting effect of (processed) red meat will be investigated. Gastrointestinal digests will be generated in vitro, and analysed using untargeted mass spectrometry based fingerprinting. In parallel, the digests will undergo geno- and cell toxicity evaluation using DNA adduct profiling, and cell lines in a new continuous long-term exposure approach. A small-scale human intervention with a strictly controlled diet will also be performed.