Nano-enabled bio-based materials can combine the best of unique functionalities: biocompatibility and sustainability. However, their development, testing and regulatory compliance processes are often far beyond the capabilities – financial and technical – of the innovators that seek to commercialise them. The EU-funded BIONANOPOLYS project aims to launch an open, innovative test bed for the design, development, testing, regulatory and environmental assessment, and upscaling of promising nano-enabled bio-based materials. With easy access to users across Europe, it will foster collaboration and innovation to secure Europe's lead in a field with growing influence in areas from packaging and coatings to biomedicine.