Research Explorer

Project

Research into new mechanisms of the anti-inflammatory function of the glucocorticoid receptor.
Code
3E000709
Duration
01 October 2009 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Medical biochemistry and metabolism
    • Endocrinology and metabolic diseases
    • Medical biochemistry and metabolism
    • Endocrinology and metabolic diseases
    • Medical biochemistry and metabolism
Keywords
glucocorticoids NF-kappaB msk1
 
Project description
 

In this project we will investigate the molecular mechanism of GC-driven nucleocytoplasmic transport of MSK1 and map the role of this export in the anti-inflammatory mechanism of GCs. Furthermore, we will also explore GC-instigated MSK1 export in vivo and possible MSK1 export via stimulation with other NR ligands. Finally we will focus on the possible phosphomodulation of GR by MSK1.