Project

Evaluation of the functional selectivity of the purino- and cannabinoid ligand-receptor system in cell migraton.

Code
01D31913
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Laboratory medicine
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Laboratory medicine
  • Engineering and technology
    • Chemical product design and formulation
    • Biomaterials engineering
Keywords
Cannabinods G-protein coupled receptors Purines
 
Project description

G-protein coupled receptors are important sites of action for many pharmacalogically active drugs. In this project, we wish to evaluate the effects of purines and cannabinoids, with cell migration as a functional read-out. To this end, we will generate transient and stable cell systems for the screening of a wide panel of (potential) ligands. This functional information (cell migration) will be coupled to biochemical information (receptor activation).