The current proposal aims at boosting the performances of photonic-chip-based Raman sensors for reaching an unprecedented detection limit of biological molecules in complex solutions. Such sensors are crucial for monitoring the presence of specific molecules or pathogens in the environment or in human bodies. Due to their intrinsic low-cost and large-scale manufacturing properties, on-chip Raman sensors can have a major societal impact in terms of public health. The key novelty of the proposal is to develop low-loss single mode waveguides operating in the UVC spectral range to overcome a fundamental scientific problem that currently limits the performances of on-chip Raman sensors. Using UV-compatible waveguides will allow us to implement on-chip resonant Raman spectroscopy, which is at least three orders of magnitude more efficient than standard Raman spectroscopy. The waveguides will be made of both amorphous aluminum oxide and single crystal diamond, materials that are both transparent in the UVC spectral range. Investigating the crystalline and amorphous phases will improve our understanding of the fundamental physical effect that currently sets the detection limit in the form of a background noise. By sensing amino-acids, nucleic acids and antibiotic solutions, we expect to demonstrate that single crystal diamond waveguides outperform amorphous material in terms of background noise.