Project

Noradrenergic modulation of innate and adaptive immune responses: Role in pathogenesis and treatment of EAE

Code
365E02317
Looptijd
01-02-2017 → 30-09-2023
Financiering
Funding by bilateral agreement (private and foundations)
Onderzoeksdisciplines
  • Medical and health sciences
    • Neurological and neuromuscular diseases
    • Neurophysiology
Trefwoorden
noradrenaline Multiple Sclerosis nervus vagus
 
Projectomschrijving

There are still important questions about the cause and optimal treatment of MS. Central to the onset of the disease is inflammation in addition to more "degenerative" non-inflammatory factors. In our research, we want to investigate how the stress hormone norepinephrine can influence these two elements of the disease. We will do this by modulating the production of norepinephrine by the brain with different techniques and by looking at how we can influence the disease in a laboratory animal model.