Project

Specific nanobodies as a tool to study the role of gelsolin in tumor cell invasion, and to perturb its activity

Duration
01 January 2008 → 31 December 2010
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
Keywords
cytoskeleton peptide aptamers tumorigenesis
 
Project description

We investigate the role of gelsolin, an actin binding protein, by using small antibodies (nanobodies) raised in llamas. The nanobodies are characterized biochemically, biophysically, and biologically and used in living (cancer) cells to modulate their behavior.