Project

Targeting epithelial receptors to switch the cross talk between enterocytes and antigen-presenting cells from tolerance to immunity.

Duration
01 October 2014 → 31 August 2020
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
Keywords
mucosal vaccines antigen targeting gastro-intestinal immunology antigen-presenting cells enterocytes
 
Project description

The intestinal immune system responds to soluble antigens with tolerance, although some antigens can induce protective immunity. Key to the oral immunogenicity of these rare antigens is receptor-mediated transcytosis. We intend to elucidate the function of the transcytosis process in the induction of intestinal immunity and how this process can be modulated to improve mucosal vaccines targeted to transcytotic receptors.