Project

Analysis of crosstalk between dietary restriction, mitochondrial function, and Ins/IGF and TOR signaling pathways that regulate life span

Duration
01 October 2008 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • General biology
  • Medical and health sciences
    • Gerontology and geriatrics
    • Medical biochemistry and metabolism
    • Gerontology and geriatrics
    • Medical biochemistry and metabolism
    • Nursing
    • Gerontology and geriatrics
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
aging dietary restriction life span C. elegans signaling mitochondrial function
 
Project description

The purpose of this study is to examine the interplay between a number of mecbanisms that control life span including dietary restriction, mitochondrial function and Ins/IFG and TOR signaling. This will be achieved by disrupting each of these pathways by mutation or RNAi and measuring the effects on oxidative stress and life span.