Evaluating the potential of nanomaterials for IP administration of chemotherapeutics and nucleic acids / Nanomedicine: an integrative approach

01 March 2019 → 31 August 2019
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Biomarker discovery
    • In vitro testing
    • Small molecules
    • Pharmaceutical technology
    • Pharmacognosy
    • Pharmacology not elsewhere classified
    • Clinical pharmacy
    • Clinical toxicology
    • Other pharmaceutical sciences not elsewhere classified
drug delivery nanocarriers topical administration
Project description

Using a step by step approach, we aim to compare injection and nebulization of chemotherapeutics and nanoparticles , by using an in-house developed model to test PIPAC in rats at clinically relevant conditions. In the first 3 years of the project, we focused on developing the nanoparticle formulation of cisplatin and the effect of nebulization on the stability of nucleic-acid containing nanoparticles. In the last year of the project, we will focus on the antitumor efficacy of injected or nebulized cisplatin nanoparticles and on the effect of size and shape on the biodistribution of nanoparticles injected or nebulized in the peritoneal cavity.