Research Explorer

Project

Omics for PATHogenic Yeasts: Host pathogen interactions in Candida vaginitis as established with dual RNA sequencing
Acronym
OPATHY
Code
01IT0718
Duration
14 March 2019 → 13 September 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Mycology
    • Genomics
    • Proteomics
    • Transcriptomics
  • Medical and health sciences
    • Inflammation
    • Clinical microbiology
    • Mycology
    • Immunogenetics
    • Mycology
    • Clinical genetics and molecular diagnostics
    • Clinical microbiology
    • Mycology
Keywords
Pathogenic yeasts next generation sequencing proteomics omics diagnostic resistance hostpathogen
 
Project description

The aim of this doctoral research is to elucidate the host-pathogen interactions in vaginal samples of women with acute and chronic Candida vaginitis as compared to women without vaginitis. For this purpose, we planned to carry out dual RNA-sequencing to detect differently expressed genes from Candida and from the host simultaneously, in clinical samples, i.e., in vaginal swabs of women with
acute and chronic candidiasis and in women that are carriers of Candida without infection.