Project

N-tert-Butanesulfinyl imidates as novel building blocks in the synthesis of bioactive compounds

Code
3E004811
Duration
01 October 2011 → 31 July 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
Keywords
addition reactions tert-butanesulfinyl imidates amino acids heterocyclic compounds
 
Project description

The goal of this project is the evaluation of chiral N-tert-butanesulfinyl imidates as novel nucleophiles in addition reactions with a range of aldehydes, ketones and imines, in Michael additions and Michael-induced ring closure reactions (MIRC) with electrophilic alkenes, in the synthesis of a variety of biologically important chiral heterocycles and -, -, -, ,-di-, ,-di- and ,,-triamino acids.