Project

Start credit for research towards novel therapies against chronic lung infections

Duration
30 September 2020 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Infectious diseases
    • Microbiome
    • Other pharmaceutical sciences not elsewhere classified
Keywords
antibiotics cystic fibrosis personalized chronic infections lung disease
 
Project description

Chronic lung infections, including in patients with cystic fibrosis, are often difficult to treat with antibiotics. Antibiotics that are effective in conventional antibiotic susceptibility assays do often not lead to clinical improvement in this patient population. Preliminary research from our laboratory indicates that lung micro-environmental factors (such as lung epithelial cells) influence the activity of antibiotics. This project aims at studying the influence of the patient-specific lung micro-environment on antibiotic efficacy.