Research Explorer

Project

Structural elucidation of the endocytic TPLATE complex
Code
01CD17023
Duration
01 July 2024 → 31 December 2024
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Plant biochemistry
  • Medical and health sciences
    • Structural bioinformatics and computational proteomics
    • Membrane structure and transport
    • Structural biology
Keywords
endocytosis structural biology integrative modelling cryo-EM Protein trafficking
 
Project description
 

Clathrin-mediated endocytosis internalizes plasma membrane proteins to react to various stimuli. In
plants, the TPLATE complex plays a crucial role in this, but how this complex orchestrates endocytosis
is unknown. This project aims to optimize the purification of the TPLATE complex and to elucidate its
ultrastructure. This will allow us to gain insight into how it functions.