Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Project

MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection

Outputs and Outcomes

Publications

The thymus road to a T cell : migration, selection, and atrophy

Mario Ruiz PérezPeter VandenabeelePeter Tougaard

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease

Cédric PelemanStig HellemansGeraldine VeeckmansWout ArrasHao ZhengIne KoekenEmily Van SanBehrouz HassanniaMagali WalravensEdissa KayirangwaNateneal Tamerat BeyeneMikhaïl Alfons Van HerckWinnok Harald De VosIsabel PintelonLuc van NassauwBaptiste OosterlinckAnnemieke SmetLieve VitsEveline DirinckAn VerrijkenJoris De ManAnnelies Van EyckWilhelmus Josephus KwantenLuisa VonghiaAnn DriessenKoen AugustynsShinya ToyokuniBenedicte De WinterChristophe Van SteenkisteSven FrancqueTom Vanden Berghe et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ferroptosis in health and disease

Carsten BerndtHamed AlborziniaVera Skafar AmenScott AytonUladzimir BarayeuAlexander BarteltHülya BayirChristina M BebberKivanc BirsoyJan P BöttcherSimone BrabletzThomas BrabletzAshley R BrownBernhard BrüneGiorgia BulliAlix BruneauQuan ChenGina M DeNicolaTobias P DickAyelén DistéfanoScott J DixonJan B EnglerJulia Esser-von BierenMaria FedorovaJosé Pedro Friedmann AngeliManuel A FrieseDominic C FuhrmannAna J García-SáezKarolina GarbowiczMagdalena GötzWei GuLinda HammerichBehrouz HassanniaXuejun JiangAicha JeridiYun Pyo KangValerian E KaganDavid B KonradStefan KotschiPeng LeiMarlène Le TertreSima LevDeguang LiangAndreas LinkermannCarolin LohrSvenja LorenzTom LueddeAxel MethnerBernhard MichalkeAnna V MiltonJunxia MinEikan MishimaSebastian MüllerHozumi MotohashiMartina U MuckenthalerShohei MurakamiJames A OlzmannGabriela PagnussatZijan PanThales PapagiannakopoulosLohans Pedrera PuentesDerek A PrattBettina PronethLukas RamsauerRaphael RodriguezYoshiro SaitoFelix SchmidtCarina SchmittAlmut SchulzeAnnemarie SchwabAnna SchwantesMariluz SoulaBenedikt SpitzlbergerBrent R StockwellLeonie ThewesOliver Thorn-SesholdShinya ToyokuniWulf TonnusAndreas TrumppPeter VandenabeeleTom Vanden BergheVivek VenkataramaniFelix C E VogelSilvia von KarstedtFudi WangFrank WestermannChantal WientjensChristoph WilhelmMichele WölkKatherine WuXin YangFan YuYilong ZouMarcus Conrad et al.

A1 Journal Article in REDOX BIOLOGY

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia RoelandtAmanda GonçalvesRiet De RyckeKodi RavichandranBart LambrechtTom TaghonGeorges LeclercqPeter VandenabeelePeter Tougaard et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

Teodora-Eugenia OlteanJonathan MaelfaitXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH DISCOVERY

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim DeclercqTom Vanden BergheJonathan MaelfaitPeter VandenabeelePeter Tougaard et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Therapeutic exploitation of ferroptosis

Magali WalravensIne KoekenTom Vanden Berghe

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi TakahashiSophie JanssensTerkild B. BuusTom TaghonGeorges LeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENCE ADVANCES

A guide to ferroptosis, the biological rust of cellular membranes

Geraldine VeeckmansEmily Van SanTom Vanden Berghe

A1 Journal Article in FEBS JOURNAL

A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs

Benjamin CappePeter VandenabeeleFranck Riquet

A1 Journal Article in FEBS JOURNAL

Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors

Camilla ScarpelliniGreta KlejborowskaCaroline LanthierBehrouz HassanniaTom Vanden BergheKoen Augustyns

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis

Benjamin CappeMike VadiEliza SackLudivine WacheulBruno VerstraetenSara DufourJulien FranckWei XieFrancis ImpensAn HendrixDenis L J LafontainePeter VandenabeeleFranck Riquet et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Emily Van SanAngela DebruyneGeraldine VeeckmansYulia Y. Y. TyurinaVladimir A. A. TyurinHao ZhengSze Men ChoiKoen AugustynsGeert van LooBernhard MichalkeVivek VenkataramaniShinya ToyokuniHuelya BayirPeter VandenabeeleBehrouz HassanniaTom Vanden Berghe et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ferroptosis and pyroptosis signatures in critical COVID-19 patients

Cédric PelemanSamya Van CoillieSymen LigthartSze Men ChoiJan De WaelePieter DepuydtDominique BenoitHANNAH SCHAUBROECKSven M. FrancqueKarolien DamsRita JacobsDominique RobertRia RoelandtRuth SeurinckYvan SaeysMohan RajapurkarPhilippe G. JorensEric HosteTom Vanden Berghe et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of RIPK1 kinase does not affect diabetes development : beta-cells survive RIPK1 activation

Tatiana TakiishiPeng XiaoMarie FranchimontEduardo H. GilglioniErick N. ArrobaEsteban N. GurzovMathieu BertrandAlessandra K. Cardozo

A1 Journal Article in MOLECULAR METABOLISM

From PERK to RIPK1 : design, synthesis and evaluation of novel potent and selective necroptosis inhibitors

Camilla ScarpelliniSophie ValemboisKenneth GoossensMike VadiCaroline LanthierGreta KlejborowskaPieter Van der VekenHans De WinterMathieu BertrandKoen Augustyns

A1 Journal Article in FRONTIERS IN CHEMISTRY

LC3-independent autophagy is vital to prevent TNF cytotoxicity

Dario PriemJon HuygheMathieu Bertrand

A1 Journal Article in AUTOPHAGY

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells

Roberto Fernández-AcostaBehrouz HassanniaJurgen CaroenBartosz WiernickiDaniel Alvarez-AlminaqueBruno VerstraetenJohan Van der EyckenPeter VandenabeeleTom Vanden BergheGilberto L. Pardo-Andreu

A1 Journal Article in CELLS

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom DelangheAllison M. BealBrad GeddesJohn BertinTom Vanden BergheJoyceline De VolderTania MaesPeter VandenabeeleBart M. VanaudenaerdeDieter DeforceSonja SkevinFilip Van NieuwerburghFien VerhammeGuy JoosSobia IdreesHerbert B. SchillerAli Önder YildirimAlen FaizMathieu BertrandGuy BrussellePhilip M. HansbroKen Bracke et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Peter VandenabeeleGeert BultynckSavvas Savvides

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells

Josephine NemegeerKelly LemeirePeter VandenabeeleJonathan Maelfait

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

Sam BlanchettYves DondelingerAlessandro BarbaruloMathieu BertrandBenedict Seddon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Spectrally tunable Förster resonance energy transfer-based biosensors using organic dye grafting

Marco Dalla VecchiaAmandine Conte-DabanBenjamin CappeWim VandenbergPeter VandenabeeleFranck RiquetPeter Dedecker

A1 Journal Article in ACS SENSORS

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

Marine GrosElodie SeguraDerek C. RookhuizenBlandine BaudonSandrine Heurtebise-ChretienNina BurgdorfMathieu MaurinEugene A. KappRichard J. SimpsonPatrycja KozikJose A. VilladangosMathieu BertrandMarianne BurbageSebastian Amigorena et al.

A1 Journal Article in CELL REPORTS

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander BotzkiLars VereeckeGeert van LooWim DeclercqSun HurPeter VandenabeeleJonathan Maelfait et al.

A1 Journal Article in NATURE

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

Bartosz WiernickiSophia MaschalidiJonathan PinneySandy Adjemian CataniTom Vanden BergheKodi RavichandranPeter Vandenabeele

A1 Journal Article in NATURE COMMUNICATIONS

Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer

Teodora-Eugenia OlteanLien LippensKelly LemeireCaroline De TenderMarnik VuylstekeHannelore DenysKatrien VandecasteelePeter VandenabeeleSandy Adjemian Catani

A1 Journal Article in FRONTIERS IN ONCOLOGY

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach

Pauline PuylaertIsabelle CoornaertCedric H. G. NeutelYves DondelingerTom DelangheMathieu BertrandPieter-Jan GunsGuido R. Y. De MeyerWim Martinet

A1 Journal Article in BIOMEDICINES

MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice

Sofie MartensNozomi TakahashiGillian BlanckeNiels VandammeHanne VerschuereTatyana DivertMarnik VuylstekeGeert BerxPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan MaelfaitNozomi TakahashiXavier SaelensPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH & DISEASE

Viral manipulation of host cell necroptosis and pyroptosis

Simon VerdonckJosephine NemegeerPeter VandenabeeleJonathan Maelfait

A1 Journal Article in TRENDS IN MICROBIOLOGY

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

Farzaneh GhazaviJelle HuysentruytJordy De ConinckStephanie KourulaSofie MartensBehrouz HassanniaTim WartewigTatyana DivertRia RoelandtBastian PopperAndreas HiergeistPeter TougaardTom Vanden BergheMarie JoossensGeert BerxNozomi TakahashiAdam WahidaPeter Vandenabeele et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA