Project

Deatailed analysis of the resistance against inflammation of Mus spretus by means of genomic techniques

Duration
01 January 2008 → 30 December 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Immunology
    • Molecular and cell biology
    • Cardiac and vascular medicine
    • Immunology
    • Cardiac and vascular medicine
    • Immunology
    • Molecular and cell biology
Keywords
inflammation Mus spretus
 
Project description

The mouse species Mus spretus, more precisely the strain SPRET/Ei, exhibits a very clear resistance against inflammation, e.g. induced by lipopolysaccharides from gram negative bacteria. This resistance is the result of a variation in signal transduction. We want to identify this variation by performing expression studies in macrophages using Affimetrix microarrays.