Research Explorer

Project

Study of the pathogenesis of arterial tortuosity by using zebrafish as a model organism
Code
01P16611
Duration
01 October 2011 → 30 September 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Molecular and cell biology
Keywords
arterial tortuosity syndrome cell lines zebrafish
 
Project description
 

The arterial tortuosity syndrome (ATS) is a recessive inherited disorder, mainly characterized by tortuosity of the arteries and caused by mutations in the SLC2A10 gene. We aim to further study the pathogenetic mechanisms in the ATS zebrafish model, that we have established previously. Finally, we will attempt to validate the zebrafish findings in a human model system using cell lines.