The P7/32 DISCOBEL network will focus on the interrelation between cell death and inflammation in an integrated approach going from the study of fundamental mechanisms in cell death, NF-kB and inflammasome to validation of concepts in inflammatory, infectious and cancer disease models and bringing them to experimental therapeutic applications in mice.
The main objectives of the DISCOBEL research program are:
To identify molecular mechanisms and signal transduction pathways that control and regulate cell death and inflammation, and their mutual interrelation.
To dissect and validate the molecular interplay between cell death and inflammation in mouse models of inflammatory and infectious, and in cancer models using state-of-the-art transgenic mouse models that are available, will be collected or newly generated within this IAPVII consortium.
To translate the fundamental knowledge generated within the consortium to experimental mouse models in order to test its potential therapeutic applicability.