Role of cell adhesion mediated signaling in craniofacial malformations: an integrated molecular morphological study

01 January 2008 → 31 October 2013
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Molecular and cell biology
    • Laboratory medicine
    • Laboratory medicine
    • Molecular and cell biology
  • Agricultural and food sciences
    • Veterinary medicine
tooth development signal transduction pathway pathology catenins animal models head structures cadherin
Project description

By analysis and generation of appropriate animal models (Xenopus, zebrafish, mouse), a multidisciplinary consortium aims at obtaining a deeper insight of the role of cell-cell adhesion molecules (cadherins, protocadherins) and associated signaling pathways (catenins, Wnt signaling) in the formation of complex head structures. Over time these models will serve the genetic analysis of human craniofacial malformations.