Development of synthetic strategies for phosphono-isoindoles and related heterocyclic phosphonates

01 October 2008 → 30 September 2012
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
synthesis phosphonates organic chemistry
Project description

Recently a new methodology for the synhesis of 2-phosphonoisoindoles from x-aminophosphonates was developed at the department of organic chemistry of the faculty of bioscience engineering. The reaction comprises a 5-exo-dig cyclisation, a [1,3]-alkyl shift and spontaneous aromatisation. This project will develop this strategy towards the synthesis of new classes of heterocyclic phosphonates and analoguous heterocycles.