My team focusses on understanding the cellular and molecular crosstalk between keratinocytes- the epithelial cells of the skin- and their microenvironment in health and disease. During injury, fast repair mechanisms are critical to maintain the skin’s barrier function and we study how epidermal stem cells communicate with fibroblasts and immune cells to orchestrate inflammation and subsequent tissue regeneration. Wound repair can however predispose tissues to cancer initiation and we aim to identify novel molecular mechanisms through which inflammation, cell death and fibrosis modulate epidermal stem cells and impact on skin regeneration and neoplasia.