Project

Nucleophilic Nanoparticles for optimal delivery of plasmid DNA in dividing cells.

Duration
01 January 2009 → 30 December 2011
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Engineering and technology
    • Chemical product design and formulation
    • Process engineering
    • Polymeric materials
    • Biomaterials engineering
Keywords
plasmid DNA
 
Project description

Plasmid DNA needs to reach the cell nucleus to be biologically active. We aim to explore new strategies to target naked DNA or DNA nanoparticles to the cell nuclei of daughter cells during the cell division of the mother cell, since during cell division the intracellular barrier of the nuclear membrane is temporarily broken down.