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Project

Molecular mechanism and functional implications of the AGR2-IRE1ß axis in goblet cell homeostasis

Information

Project Team

Outputs and Outcomes

Publications

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Lisa NeidhardtEva ClootsNatalie FriemelCaroline A M WeissHeather P HardingStephen H McLaughlinSophie JanssensDavid Ron

A1 Journal Article in EMBO JOURNAL

2024

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

2024