Project

Analysis of glycosylation changes on the surface of lymphocytes and their pathophysiological relevance during chronic necro-inflammation

Duration
01 October 2011 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analytical chemistry
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
inflammation proteomics glycomics
 
Project description

The project aims at studying the glycosylation changes on proteins of the lymphocytes' cell surface. Moreover, we want to develop proteomics technology in order to identify the proteins showing these glycosylation changes. In a later stage of the project, we will interfere with these glycosylation pathways in disease models for chronic necro-inflammation to assess to what extent these pathways can serve as drug targets.