Research Explorer

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Project

The role of Rab27B-mediated exocytosis in infiltrative tumor growth and metastasis.

Outputs and Outcomes

Code

01P13610

Duration

01 October 2010 → 01 October 2012

Funding

Regional and community funding: Special Research Fund

Promotor

Marc Bracke

Research disciplines

Medical and health sciences
- Morphological sciences
- Oncology
- Morphological sciences
- Oncology
- Morphological sciences
- Oncology

Keywords

vesicle transport breast cancer Rab GTPase

Project description

The secretory small GTPase Rab27B masters the release of pro-invasive growth regulators in poor prognosis ER-positive breast cancer. In this research project we characterize the Rab27B-vesicles, identify the effector used to traffic Rab27B-vesicles towards the cell periphery, study effector involvement in invasive tumor growth, and translate the experimental data to the clinic by validating Rab27B effector status in primary breast cancer.

English

Dutch

English

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