Project

Functional study of the ALK-F1174 mutation in

Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
    • Other biological sciences
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
Keywords
neuroblastoma ALK-pathway therapy
 
Project description

Neuroblastoma, the third most frequent childhood tumor, accounts for 15% of childhood cancer mortality. In-depth knowledge of ALK downstream signaling and identification of new vulnerable nodes for treatment is needed in order to design multi-compound oriented treatment. It is anticipated that such therapy can drastically reduce the chances of acquiring resistant phenotypes. In order to optimize targeted treatment, this project will further study growth promoting signaling in neuroblastoma cells carrying the ALKF1174L mutation as well as the molecular basis underlying the cooperative oncogenic effect between ALKF1174L mutation and MYCN amplification.